Disruptive Reproductive Technologies: In vitro fertilization (IVF) represented a transformative technological innovation. Now in vitro gametogenesis (IVG)–the generation of eggs and sperm from pluripotent stem cells in a culture dish–is is poised for future success in humans and promises new possibilities for the fields of reproductive and regenerative medicine. At the same time, IVG raises vexing ethical and social policy challenges in need of redress. Here, we describe the state of relevant IVG science and discuss the promise, challenges, and regulatory and ethical implications of IVG.
